What is Biofiller and how does it work?


Bio-filler facelift is a great alternative treatment to offer your clients instead of Hyaluronic acid filler.

The Bio-filler Facelift with Plasma Gel is now the most exciting medical aesthetic process we have introduced; it involves  auto-transfer with Plasma Gel injections derived from the patient’s own blood and excludes risk of allergic reactions.

Plasma Gel can be gained and utilised for wrinkle augmentation in a single session. This Bio-filler Gel can be used to augment very fine lines and wrinkles as well as larger areas of the facial skin that need to be treated. The Plasma Gel is made by processing the patient’s own blood and in turn it is injected to volumize, lift, and rejuvenate the face, neck and hands. Plasma Gel has the same colour and form as autologous fat, but when injected, the softness is much better than autologous fat and it allows for as it is more precise and refined. 

How does platelet poor plasma work as a dermal filler alternative?

PPP may be used as an alternative to dermal filler or in conjunction with it. When PPP is injected into the skin it helps to stimulate the deeper tissues to produce collagen and increase volume, also most practitioners will mix it with PRP once it has cooled down, so then it can help release growth factors as the biofiller breaks down . Unlike dermal fillers which produce long lasting volume, Biofiller acts to provide some volume while also stimulating the body’s own collagen (*). When the body’s own natural collagen is stimulated, Biofiller will help to naturally restore facial volume, remodel the tissue and improve facial lines, wrinkles, and folds such as the nasolabial folds and marionette lines.

The first results are visible immediately after the treatment and effects of the neocollagenesis (new collagen) production can be seen after a couple of weeks. After a couple of months the plasma gel is naturally and completely absorbed in the treated area. We suggest a course of 3 sessions with a 4-week interval. The results last for about 2 years after the 3rd session if it is combined with PRP serum injection. However when advising to the client I usually advise 2 sessions 4 week apart and lasts around 6 months to a year. If mixed with prp, as the biofiller breaks down it will also help in improving the area of the face that has suffered volume loss.

In facial aesthetics and plastic surgery it was trying to work out how to overcome the rapid degradation of plasma and keep volume stabilisation.  A novel technique was developed whereby platelet-poor plasma containing mainly 60% Albumin is heated at 75 Celsius for ten minutes to allow for the denaturation and breaking of the weak linkages or bonds (eg hydrogen bonds) within its protein molecule. Following this process the proteins are then restructured in a more densely organised protein structure with extended resorption properties from 2 weeks upto 4-6 months. However despite the longer lasting heat treated PRF/PPP, a lower regenerative potential is easily expected, since no cells/growth factors in the heat treated PRF/PPP are capable of enduring the denaturation process (thermal heating).

Albumin  plays a big part in creating the plasma gel– Serum Albumin is a versatile carrier protein, and one of the most important blood proteins. High temperatures is known to cause protein denaturation by changing the protein’s secondary structure. It is a family of proteins, most common ones are the serum albumins. All albumins are water-soluble proteins and are commonly found in the blood.

Human serum albumin – makes up 50% of the plasma proteins and one of the main proteins of humans blood. It binds with water, hormones, fatty acids, bilirubin, thyroxine and other drugs. Its main function is to regulate the osmotic pressure (the small amount of pressure needed for the blood to carry on in a inward flow) of blood.

Example of a protein being heated going through denaturation and reconstructing